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Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression BJMBR
Ribeiro,M.D.; Onusic,G.M.; Poltronieri,S.C.; Viana,M.B..
Erythrina velutina (EV) and Erythrina mulungu (EM), popularly used in Brazil as tranquilizing agents, were studied. The effects of acute and chronic oral treatment with a water:alcohol extract of EV (7:3, plant grounded stem bark; acute = 100, 200, 400 mg/kg; chronic = 50, 100, 200 mg/kg) were evaluated in rats (N = 11-12) submitted to the elevated T-maze (for avoidance and escape measurements) model of anxiety. This model was selected for its presumed capacity to elicit specific subtypes of anxiety disorders recognized in clinical practice: avoidance has been related to generalized anxiety and escape to panic. Additionally, animals were treated with the same doses of EV and EM (water:alcohol 7:3, inflorescence extract) and submitted to the forced swim...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Erythrina velutina; Erythrina mulungu; Elevated T-maze test; Forced swim test; Anxiety; Depression.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200013
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Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress J. Venom. Anim. Toxins incl. Trop. Dis.
Reddy,C. M.; Gawade,S. P..
Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obtained by exposing the venom to ultraviolet radiation (UVR) in the presence of methylene blue. The aim of the present study was to evaluate the effects of POECVP on learning, memory and stress in rats. Detoxification of the photooxidized venom was evident since the POECVP-treated group had longer survival time than the group of mice treated with Echis carinatus venom product (ECVP) following intraperitoneal and intracerebral injections. Photooxidized Echis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Learning and memory; Photooxidized Echis carinatus venom product; T-maze; Forced swim test; Elevated plus-maze.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400010
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